Wednesday 20 June 2018

Comparison of local recurrence among early breast cancer patients treated with electron intraoperative radiotherapy vs hypofractionated photon radiotherapy: an observational study

Comparison of local recurrence among early breast cancer patients treated with electron intraoperative radiotherapy vs hypofractionated photon radiotherapy: an observational study: PURPOSE: To evaluate local recurrence (LR) in women with early breast cancer (BC) who underwent intraoperative radiation therapy with electrons particles (IORT-E) or adjuvant hypofractionated external radiotherapy (HYPOFX). MATERIALS AND METHODS:We retrospectively analyzed 470 patients with early BC treated at our center from September 2009 to December 2012. 235 women were treated with breast-conserving surgery and immediate IORT-E (21 Gy/1 fraction) while 235 patients underwent wide excision followed by hypofractionated whole breast irradiation. Radiotherapy modality was chosen according an individualized decision based on tumour features, stage, technical feasibility, age, acceptance to be enrolled in the IORT-E group.RESULTS: After a median follow-up of 6 years, we observed 8 (3.4%) and 1 (0.42%) LR in the IORT-E and in the HYPOFX group (p=0.02), respectively. The two groups differed in the prevalence of clinical characteristics (p4 and 1 women in the IORT-E and HYPOFX group died for breast cancer, respectively (p=0.167). OS and DFS hazard ratio [HR] were 2.14 (95% IC, 1.10 to 4.15) and 2.09 (95% IC, 1.17 to 3.73), respectively. CONCLUSIONS:Our comparison showed that IORT-E and HYPOFX are two effective radiotherapy modalities after conservative surgery in early BC. However, at 6 years a significant higher rate of LR occurred in patients submitted to IORT-E with respect to HYPOFX. This finding may be correlated to some subsets of patients who, depending on the biological...

4 comments:

  1. Believe me I have used Dr Aziba herbal Medicine cure remedy for 2 WEEKS now. So far, it has cured my HERPES, eliminated my COLD SORE, improved energy and metabolism, in the morning I feel recharged and I no longer feel sleepy after a meal. As for the scent, it does smell like motor oil but I chase it down with 100% Herbal medicine from Dr Aziba. twice a day AFTER a meal. I also experienced vivid dreams for about 5 days now it’s diminishing to during the first 2 or 3 hours of sleep . contact Dr Aziba: EMAIL: priestazibasolutioncenter@gmail.com or whatsapp +2348100368288 and He also have herbs medicine to cure some popular diseases....
    Some other disease disturbing your health get connected with Dr Aziba for the herbal cure

    ReplyDelete
  2. I'm so happy to testify of the good work of Dr Agbomina , I Suffer from Herpes virus since 2007 and i had frequent symptoms in my private area, after some time it will go away after using acyclovir drugs, then come back after some months. it was disheartening since i have been diagnosed, but after finding Dr Agbomina and his reviews i was convinced that he will definitely cure me and so i contacted and he told me how to get his medicine and using it for just 14 days and i will go and check up and first i said how can that be possible but i used his herbal medicine after making purchase and truly i used it and went for the test again, and my result came back negative. so i made it a task to share this good testimony in the internet so that those sick can benefit and get cured. What app or call: +2349039139161 Or Email: dragbonherbalmedicine@gmail.com

    ReplyDelete
  3. Hello views join my to appreciate Dr. Ajayi for the great work he did for me, that have be my happiest day in my life this true life story you should pickup a point. I have been diagnose of herpes virus for years,I’ve lost all hope and that there is no cure and I have been taken medicine to sustain myself till I got to know about Dr. Ajayi through a friend who he cured of herpes. I contacted him and he sent me his herbal remedy which I took as he directed me to do for some days and I went to the hospital after consuming his Herbal medicine and I was confirmed herpes Negative after years of pains and suffering , it is indeed a miracle, Dr. Ajayi is a great man, I have heard so much about how he has help lot of people, if you have any issue you can contact him for help.via email him on. ajayiherbalhome@gmail.com  you can as well call his mobile number or add him on whatsapp +2348154724883..

    ReplyDelete
  4. God bless Dr. USELU for his marvelous work in my life, I was diagnosed of HERPES SIMPLEX VIRUS since 2018 and I was taking my medications, I wasn't satisfied i needed to get the HERPES out of my system, I searched about some possible cure for HERPES i saw a comment about Dr. USELU , how he cured HERPES with his herbal medicine, I contacted him and he guided me. I asked for solutions, he started the remedy for my health, he sent me the medicine within 3 days. I took the medicine as prescribed by him and 2 weeks later i was cured from HERPES contact him via email (dr.uselucaregiver@gmail.com) once again thanks to you Dr. USELU cure the flowing virus, contact his email or add him on whatsapp (+2349019328641) cancer cure
    diabetes cure
    ringing ear
    herpes cure
    warts cure
    HPV cure
    HIV cure
    get your ex back
    pregnancy herbal medicine
    Hepatitis    

    ReplyDelete