It «is a comprehensive genomic profiling test combining DNA (deoxyribonucleic acid) sequencing of 406 genes and RNA (ribonucleic acid) sequencing of 265 genes for patients with hematologic malignancies, sarcomas or solid tumors where RNA sequencing is desired [1].» It «detects known, novel, and complex fusion events as well as other common genomic alterations [2]» «(base substitutions, insertion and deletions [indels], [...] copy number alterations [CNAs] [3], and copy number variations [CNVs]) (...) to identify potential targeted therapy options, detect alterations in prognostic genes, and sub-classify sarcoma diagnoses [2].» It identifies «somatic genomic alterations in genes known to be unambiguous drivers of hematologic malignancies (...) and sarcomas [3].» It «is validated to detect the four main classes of genomic alterations in more than 400 cancer-related genes [4].»
Bibliographic references:
[1] Foundation Medicine. 2020. Foundationone Heme. [online] Available at: <https://corpsite.foundationmedicine.com/genomic-testing/foundation-one-heme> [Accessed 4 October 2020].
[2] Foundationmedicine.com. 2020. Foundationone Heme | Foundation Medicine. [online] Available at: <https://www.foundationmedicine.com/test/foundationone-heme> [Accessed 4 October 2020].
[3] Foundationmedicineasia.com. 2017. Foundationone®Heme - Technical Information. [online] Available at: <https://www.foundationmedicineasia.com/content/dam/rfm/apac_v2-en/FoundationOne_Heme_Technical_Information.pdf> [Accessed 4 October 2020].
[4] Foundation Medicine. 2020. Foundation Medicine. [online] Available at: <https://www.foundationmedicine.ca/foundationOneHeme.aspx> [Accessed 4 October 2020].
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