Rs of radiobiology

The most important biological factors influencing tumor and normal tissue responses to fractionated treatment are referred to as the Rs [1]:

1. Repair [1]/Recovery [2];
2. Re-assortment/Redistribution [1,2];
3. Repopulation [1,2];
4. Reoxygenation [1,2];
5. Radiosensitivity [1,2];
6. Reactivation of anti-tumor immune response [1];
7. intrinsic Radiosensitivity [2];
8. iRradiated volume [2];
9. long-term Restoration [2];
10. molecular Radiopathology [2].

Bibliographic references:

[1] Boustani J, Grapin M, Laurent PA, Apetoh L, Mirjolet C. The 6th R of Radiobiology: Reactivation of Anti-Tumor Immune Response. Cancers (Basel). 2019 Jun 20;11(6):860. Available at: https://dx.doi.org/10.3390%2Fcancers11060860.

[2] Dörr W. Radiobiology of tissue reactions. Ann ICRP. 2015;44(1 Suppl):58–68. Available at: https://doi.org/10.1177/0146645314560686.