Saturday 18 August 2018

Basket study

Source: [4].

«Basket trials (or studies) test the effect of one drug on a single mutation in a variety of tumor types [baskets], at the same time. These studies also have the potential to greatly increase the number of patients who are eligible to receive certain drugs relative to other trials designs [1], «allowing researchers to analyze each cancer type individually, as well as assess the impact of the drug or drug combinations as a whole. Using this approach, it is possible to combine what would have been multiple phase 2 trials into a single study [4]». «In the evaluation of targeted therapies, basket trials have emerged as an approach to test the hypothesis that targeted therapies may be effective independent of tumor histology, as long as the molecular target is present [2].» «Most basket trials typically aim to answer multiple questions simultaneously [3].»

Bibliographic references:
[1] Clinical Trial Design and Methodology. ASCO. https://www.asco.org/research-progress/clinical-trials/clinical-trial-resources/clinical-trial-design-and-methodology. Accessed August 18, 2018.
[2] Redig AJ, Jänne PA. Basket trials and the evolution of clinical trial design in an era of genomic medicine. J Clin Oncol. 2015 Mar 20;33(9):975-7. Available at: https://doi.org/10.1200/JCO.2014.59.8433.
[3] Cunanan KM, Gonen M, Shen R, et al. Basket Trials in Oncology: A Trade-Off Between Complexity and Efficiency. J Clin Oncol. 2017 Jan 20;35(3):271-273. Available at: https://doi.org/10.1200/JCO.2016.69.9751.
[4] Illuminating ideas: Innovative clinical trial design. Roche.com. https://www.roche.com/research_and_development/who_we_are_how_we_work/clinical_trials/innovative-clinical-trial-design.htm. Accessed August 18, 2018.

11 comments:

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  3. Hello everyone i’m so grateful to DR. KOFI for curing me completely from herpes virus . I was told i have herpes in 2011, i have been taking different kinds of medication still yet no improvement until i saw testimonies of DR. KOFI curing Herpes, Diabetes, HIV and other disease i was skeptical about contacting him but i also knew the importance of herbal medicine, i made up my mind and contacted him we talked on phone and he prepared and gave me medicine which i took according to his dosage information. Now I’m so happy I’m cured from Herpes my heart is so filled with joy, thank you so much DR. KOFI . If you are reading this and you have Herpes or any kind of disease contact him today Email: drkofiherbalcure@gmail.com ..mobile:WHATSAPP HIM OR CALL+2349039139161. He cure listed diseases

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  7. Hi, is a true life experience is not designed to convince you its a personal health experience, sometimes medical doctors take a different approach about herpes treatment. i has been stocked in bondage with herpes for two years and four months i has tried different means to eliminate this sickness because it surely has distract me even with the world, and i was told there is no cure, but only medicine for treatment all the possible ways i has tried was treatment, two months back i did some herpes research and i found amazing testimonies concerning natural herbal cure, and i go for it through the email address from the post just to give a try of herbal treatment, and i found it grate without delay i got cured with natural treatment from doc Onokun herbal cure his cure are powerful and shows out excellent result. and i think everyone suffering with herpes and others symptoms should also know about this cure from, Dronokunherbalcure@gmail.com  

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