It describes the
proliferation rate of the tissues, which can be measured from
biopsies by flow cytometry after administration in situ to the
patient of a deoxyribonucleic acid thymidine tracer [2]. "This is difficult to determine in vivo." It is "the time which the cell population of tumor doubles if there is no cell loss" [3]. Tp (potential
doubling time or cell doubling time after cell loss) is a little shorter than Tpot (measured
before the tumour has received any cytotoxic treatment) [1].
Pretreatment Tpot measured in human
tumor biopsies [2].
|
||
Tumor
|
Median (days)
|
Range (days)
|
Larynx
|
4
|
2-19
|
Tongue
|
4-6
|
2-16
|
Mouth, cheek
|
3.4
|
2-15
|
Esophagus
|
5
|
2.5-20
|
Cervix
|
5
|
3-20
|
Rectum
|
5
|
3-18
|
Prostate
|
42
|
15-70
|
Breast
|
14
|
3-70
|
Bibliographic references:
[1] Fowler, JF. 21 years of
Biologically Effective Dose. Br J Radiol. 2010 Jul; 83(991): 554–568.
Available at: http://dx.doi.org/10.1259%2Fbjr%2F31372149.
[2] Fowler JF.
The radiobiology of prostate cancer including new aspects of
fractionated radiotherapy. Acta Oncol. 2005;44(3):265-76.
Available at: http://dx.doi.org/10.1080/02841860410002824.
[3] The timely delivery of radical radiotherapy: standards and guidelines for the management of unscheduled treatment interruptions. (2008). 3rd ed. London, United Kingdom: Board of Faculty of Clinical Oncology, The Royal College of Radiologists. Available at: https://www.rcr.ac.uk/sites/default/files/publication/BFCO(08)6_Interruptions.pdf [Accessed 17 Jul. 2016].
[3] The timely delivery of radical radiotherapy: standards and guidelines for the management of unscheduled treatment interruptions. (2008). 3rd ed. London, United Kingdom: Board of Faculty of Clinical Oncology, The Royal College of Radiologists. Available at: https://www.rcr.ac.uk/sites/default/files/publication/BFCO(08)6_Interruptions.pdf [Accessed 17 Jul. 2016].
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