Reirradiation of skin tumors

Slides from Anita O'Donovan, Assistant Professor, Discipline of Radiation Therapy, Trinity College, Dublin, Ireland.
In ESTRO course on Multidisciplinary Management of Non-Melanoma Skin Cancer, Brussels, Belgium, November 9, 2019.

Link to Virginia M. (2016). Reirradiation of Skin Tumors. M J Canc. 1(1): 003: https://www.mathewsopenaccess.com/scholarly-articles/reirradiation-of-skin-tumors.pdf.

EORTC-1333-GUCG PEACE III trial - Interview Prof. Bertrand Tombal

GUCG = Genito-Urinary Cancers Group; EORTC; PEACE = Prostate Cancer Consortium in Europe.

Accelerated hyperfractionation

It is the combined rationales of accelerated fractionation and hyperfractionation: «increase in fraction number, reduction in fraction size and treatment time, compared with conventional.»

Bibliographic reference: Thames HD Jr, Peters LJ, Withers HR, Fletcher GH. Accelerated fractionation vs hyperfractionation: rationales for several treatments per day. Int J Radiat Oncol Biol Phys. 1983 Feb;9(2):127-38. Available at: https://doi.org/10.1016/0360-3016(83)90089-5.

Accelerated fractionation

«Overall time shorter than conventional, achieved by giving 2 or 3 doses daily; total dose and fraction size similar to conventional.»

Bibliographic reference: Thames HD Jr, Peters LJ, Withers HR, Fletcher GH. Accelerated fractionation vs hyperfractionation: rationales for several treatments per day. Int J Radiat Oncol Biol Phys. 1983 Feb;9(2):127-38. Available at: https://doi.org/10.1016/0360-3016(83)90089-5.

Image-guided radiation therapy (IGRT)

IGRT is the «radiotherapy that uses image guidance procedures for target localization before and during treatment. These procedures use imaging technology to identify and correct problems arising from inter- and intrafractional variations in patient setup and anatomy, including shapes and volumes of the treatment target(s), organs at risk, and surrounding normal tissues. The goal of IGRT is to reduce the geometrical uncertainty in a given treatment fraction by evaluating the patient geometry at the time of treatment and either altering the patient position or adapting the treatment plan with respect to anatomical changes that occur during the radiotherapy treatment course.»

Bibliographic reference: Xiao Y. Image-Guided Radiation Therapy (IGRT): kV Imaging. In: Brady LW, Yaeger TE (Eds), Encyclopedia of Radiation Oncology. Berlin, Heidelberg: Springer, Berlin, Heidelberg; 2013. p. 343.