It is a stereotactic radiotherapy with dose by a fraction greater than 8 Gy, that allows stopping both cellular division and cellular function, overwhelms tumor repair, and is more likely to cause «late» effects.
Bibliographic reference: Timmerman RD. An overview of hypofractionation and introduction to this issue of seminars in radiation oncology. Semin Radiat Oncol. 2008 Oct;18(4):215-22. Available at: https://doi.org/10.1016/j.semradonc.2008.04.001.
